In Conan the Barbarian, James Earl Jones plays this shapeshifting snake lord. In the comics, Thulsa Doom had a skeleton's face, so that just shows you how far facial reconstruction surgery has come.
Grig from The Last Starfighter
One of the rare good lizard humanoids in science fiction, Grig is an affable co-pilot from The Last Starfighter. We assume he constantly suppresses the urge to devour the little boy he flies next to.